Abstract
The rank order of potency for the physiological effects of three phenethylamine hallucinogens in the locus coeruleus (LC) was identical to that previously shown for their 5-HT2 binding affinity [-) DOB greater than DOM greater than ( + )DOB). The behaviorally inactive positional isomer of DOB, SL-7161, did not significantly affect LC unit activity. These results offer insight into structure-activity relationships at 5-HT2 receptors and support earlier findings that the actions of hallucinogens displayed in the LC are mediated via 5-HT2 receptors.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amphetamines / pharmacology*
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Animals
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DOM 2,5-Dimethoxy-4-Methylamphetamine / analogs & derivatives
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DOM 2,5-Dimethoxy-4-Methylamphetamine / pharmacology*
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Dose-Response Relationship, Drug
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Electric Stimulation
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Evoked Potentials / drug effects
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Isomerism
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Locus Coeruleus / drug effects*
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Locus Coeruleus / metabolism
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Male
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Rats
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Rats, Inbred Strains
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Receptors, Serotonin / metabolism*
Substances
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Amphetamines
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Receptors, Serotonin
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DOM 2,5-Dimethoxy-4-Methylamphetamine