Altered dihydrofolate reductase associated with a pyrimethamine-resistant Plasmodium berghei berghei produced in a single step

Nature. 1970 Nov 7;228(5271):579-80. doi: 10.1038/228579a0.
No abstract available

MeSH terms

  • Animals
  • Cricetinae
  • Drug Resistance, Microbial*
  • Malaria / enzymology
  • Mice
  • Plasmodium / enzymology*
  • Pyrimethamine / pharmacology*
  • Tetrahydrofolate Dehydrogenase / analysis*

Substances

  • Tetrahydrofolate Dehydrogenase
  • Pyrimethamine