Abstract
Trypsin immobilised on polystyrene beads causes initiation of cell division which cannot be accounted for by trypsin released into the medium or into the cells. Also, initiation by soluble trypsin is inhibited by immobilised soybean trypsin inhibitor. These results demonstrate that trypsin can initiate proliferation at the cell surface.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Cell Division / drug effects*
-
Cell Membrane / drug effects*
-
Cell Membrane / metabolism
-
Cells, Cultured
-
Chick Embryo
-
Enzymes, Immobilized / metabolism
-
Mitogens
-
Polystyrenes / pharmacology
-
Solubility
-
Trypsin / metabolism
-
Trypsin / pharmacology*
-
Trypsin Inhibitors / pharmacology
Substances
-
Enzymes, Immobilized
-
Mitogens
-
Polystyrenes
-
Trypsin Inhibitors
-
Trypsin