Abstract
Cell membrane receptors for hormones and neurotransmitters form oligomeric complexes with GTP-regulatory proteins and inhibit the latter from reacting with GTP. Hormones and neurotransmitters act by releasing the inhibitory constraints imposed by the receptors, thus allowing the GTP-regulatory proteins to interact with and control the activity of enzymes such as adenylate cyclase. This theory may apply generally to membrane signal transduction involving surface receptors.
MeSH terms
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Adenylyl Cyclase Inhibitors
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Adenylyl Cyclases / metabolism*
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Animals
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Carrier Proteins / physiology
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Cyclic AMP / metabolism
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Enzyme Activation
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Guanosine Triphosphate / physiology*
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Humans
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Macromolecular Substances
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Membrane Proteins / physiology
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Neurotransmitter Agents / pharmacology
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Receptors, Cell Surface / physiology
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Receptors, Drug / physiology*
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Receptors, Neurotransmitter / physiology
Substances
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Adenylyl Cyclase Inhibitors
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Carrier Proteins
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Macromolecular Substances
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Membrane Proteins
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Neurotransmitter Agents
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Receptors, Cell Surface
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Receptors, Drug
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Receptors, Neurotransmitter
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Guanosine Triphosphate
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Cyclic AMP
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Adenylyl Cyclases