Abstract
The article first includes a discussion on the classification of catecholamine receptors followed by a discussion on the binding studies of beta-receptors and their affinity labeling. Next a brief discussion on the solubilization and the current attempts to purify the receptor is presented. A large section is then devoted to the mode of coupling between beta-receptors and cyclase where much space is devoted to the role of GTP and of the membrane matrix. The review ends with a discussion on beta-receptor desensitization, supersensitivity, and the "spare receptor" concept.
MeSH terms
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Adenylyl Cyclases / metabolism*
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Adrenergic beta-Antagonists / metabolism
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Affinity Labels
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Animals
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Calcium / metabolism
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Catecholamines / metabolism
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Cell Membrane / metabolism
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Chemical Phenomena
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Chemistry
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Cholera Toxin / pharmacology
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Forecasting
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Guanosine Triphosphate / pharmacology
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Humans
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Kinetics
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Membrane Lipids / physiology
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Radioligand Assay
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Receptors, Adrenergic / physiology*
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Receptors, Adrenergic, alpha / physiology
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Receptors, Adrenergic, beta / drug effects
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Receptors, Adrenergic, beta / physiology*
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Receptors, Dopamine / metabolism
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Structure-Activity Relationship
Substances
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Adrenergic beta-Antagonists
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Affinity Labels
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Catecholamines
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Membrane Lipids
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Receptors, Adrenergic
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Receptors, Adrenergic, alpha
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Receptors, Adrenergic, beta
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Receptors, Dopamine
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Guanosine Triphosphate
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Cholera Toxin
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Adenylyl Cyclases
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Calcium