Abstract
Intrathecal injection of substance P in mice elicited a dose-related biting and scratching response. Systemic but not intrathecal morphine sulfate antagonized this response. We interpret these observations to define a novel nociceptive response to intrathecal substance P.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Afferent Pathways / physiology
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Animals
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Behavior, Animal / physiology*
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Dose-Response Relationship, Drug
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Injections, Spinal
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Male
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Mice
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Morphine / pharmacology
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Neural Inhibition / drug effects
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Nociceptors / physiology*
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Spinal Cord / physiology
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Substance P / physiology*
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Synaptic Transmission / drug effects