A 63-year-old woman developed anicteric hepatitis after two weeks of therapy with ranitidine. Despite continuation of therapy, her symptoms resolved within five days and transaminase levels returned to normal in the next four weeks, at which time use of the drug ceased. The gamma-glutamyl transpeptidase level returned to normal two weeks later. Although liver biopsy and drug rechallenge were not performed, no other cause for the reaction could be found.