Abstract
Various proenkephalin-derived peptides such as peptide E and the bovine adrenal medulla peptides BAM-12P and BAM-22P are potent competitors on mu and kappa binding sites in guinea pig brain sections. Moreover, they are all potent agonists in the rabbit vas deferens, a specific kappa opiate receptor bioassay. As described before, dynorphin and some of its fragments are also potent kappa agonists. Our results suggest that not only prodynorphin-derived peptides could act as endogenous kappa ligands but also some proenkephalin-derived peptides such as peptide E.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adrenal Medulla
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Animals
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Biological Assay
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Brain / metabolism*
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Enkephalin, Methionine / analogs & derivatives
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Enkephalin, Methionine / pharmacology
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Enkephalins / pharmacology*
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Guinea Pigs
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Ileum / drug effects
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Kinetics
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Male
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Mice
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Muscle Contraction / drug effects
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Peptides / pharmacology*
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Protein Precursors / pharmacology
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Receptors, Opioid / drug effects
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Receptors, Opioid / metabolism*
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Receptors, Opioid, kappa
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Structure-Activity Relationship
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Vas Deferens / drug effects
Substances
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Enkephalins
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Peptides
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Protein Precursors
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Receptors, Opioid
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Receptors, Opioid, kappa
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Enkephalin, Methionine
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BAM 12P
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BAM 22P
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peptide E (adrenal medulla)