Abstract
A large number of structurally diverse drugs with clinical antidepressant properties share the ability to act as potent inhibitors of histamine-sensitive adenylate cyclase in cell-free preparations from mammalian brain. This common biochemical action may represent part of the molecular basis for the antidepressant properties of these compounds.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Adenylyl Cyclase Inhibitors
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Adenylyl Cyclases / metabolism
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Animals
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Antidepressive Agents, Tricyclic / pharmacology*
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Biogenic Amines / metabolism
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Brain / drug effects*
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Brain / enzymology
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Brain / metabolism
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Enzyme Activation / drug effects
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Guinea Pigs
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Histamine / metabolism
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Histamine / physiology
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In Vitro Techniques
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Kinetics
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Monoamine Oxidase Inhibitors / pharmacology
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Receptors, Histamine / drug effects*
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Receptors, Histamine / metabolism
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Structure-Activity Relationship
Substances
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Adenylyl Cyclase Inhibitors
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Antidepressive Agents, Tricyclic
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Biogenic Amines
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Monoamine Oxidase Inhibitors
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Receptors, Histamine
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Histamine
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Adenylyl Cyclases