Abstract
Treatment of mice with diethyl maleate (DEM) or buthionine sulfoximine (BSO) significantly enhanced the lung injury caused by butylated hydroxytoluene (BHT). Conversely, cysteine protected mice from the lung toxicity of BHT. BHT administration to mice produced a time-dependent reduction of glutathione (GSH) content in the lung, but not in the liver. These results support the concept that conjugation of 2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone (BHT-quinone methide), a proposed reactive metabolite of BHT, with GSH is involved in the detoxification of BHT in mice.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Body Weight / drug effects
-
Buthionine Sulfoximine
-
Butylated Hydroxytoluene / antagonists & inhibitors
-
Butylated Hydroxytoluene / metabolism
-
Butylated Hydroxytoluene / toxicity*
-
Cysteine / pharmacology*
-
Drug Synergism
-
Glutathione / metabolism*
-
Liver / metabolism
-
Lung / drug effects*
-
Lung / metabolism
-
Male
-
Maleates / toxicity*
-
Methionine Sulfoximine / analogs & derivatives*
-
Methionine Sulfoximine / toxicity
-
Mice
-
Organ Size / drug effects
Substances
-
Maleates
-
Methionine Sulfoximine
-
Butylated Hydroxytoluene
-
Buthionine Sulfoximine
-
diethyl maleate
-
Glutathione
-
Cysteine