Abstract
The effects of intraperitoneal NG-methyl-L-arginine and N omega-nitro-L-arginine methyl ester, specific inhibitors of nitric oxide (NO) synthase, were examined on the pentylenetetrazol (PTZ)-induced seizures in rats. The incidence and latency for the onset of myoclonic jerks, clonic seizures, and tonic generalized extension were observed as specific parameters among PTZ-induced seizures. Both drugs preferentially suppressed the tonic generalized extension and prolonged the latency for the onset of each parameter, suggesting NO has a significant effect on the PTZ-induced seizure.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Oxidoreductases / antagonists & inhibitors*
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Animals
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Arginine / analogs & derivatives*
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Arginine / pharmacology
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Calmodulin-Binding Proteins / antagonists & inhibitors*
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Epilepsy / chemically induced
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Epilepsy / drug therapy*
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Male
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NG-Nitroarginine Methyl Ester
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Nitric Oxide Synthase
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Pentylenetetrazole
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Rats
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Rats, Wistar
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omega-N-Methylarginine
Substances
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Calmodulin-Binding Proteins
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omega-N-Methylarginine
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Arginine
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Nitric Oxide Synthase
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Amino Acid Oxidoreductases
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NG-Nitroarginine Methyl Ester
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Pentylenetetrazole