Abstract
The efficacy of cystine, ascorbate and trolox, a vitamin E analogue, at protecting against nitric oxide-mediated mitochondrial complex IV damage has been investigated in cultured astrocytes. Of these compounds, only trolox afforded protection. It is suggested that lipid peroxidation is responsible for nitric oxide-mediated mitochondrial damage and that inhibitors of this process may be of therapeutic benefit in conditions where excessive nitric oxide production is implicated.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Oxidoreductases / biosynthesis*
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Animals
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Ascorbic Acid / pharmacology
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Astrocytes / drug effects
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Astrocytes / enzymology
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Astrocytes / ultrastructure*
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Chromans / pharmacology*
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Cystine / pharmacology
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Electron Transport Complex IV / drug effects*
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Electron Transport Complex IV / metabolism
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Enzyme Induction
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Interferon-gamma / administration & dosage
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Lipid Peroxidation
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Lipopolysaccharides / pharmacology
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Mitochondria / drug effects
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Mitochondria / enzymology*
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Nitric Oxide / adverse effects*
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Nitric Oxide Synthase
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Rats
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Rats, Wistar
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alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / antagonists & inhibitors*
Substances
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Chromans
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Lipopolysaccharides
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Nitric Oxide
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Cystine
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alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
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Interferon-gamma
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Nitric Oxide Synthase
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Amino Acid Oxidoreductases
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Electron Transport Complex IV
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Ascorbic Acid
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6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid