Abstract
Treatment with pivalic acid containing prodrugs has been shown to cause carnitine depletion by loss of pivaloyl carnitine in urine. A 7-day standard pivmecillinam treatment of adults lead to a marked decrease of the free serum carnitine concentration (44.6 to 12.9 mumol/liter), whereas no change was seen in those given norfloxacine (40.0 to 40.5 mumol/liter). In some patients irrespective of age the free serum carnitine concentration was decreased to levels (around 10 mumol/liter) at which an impaired ketone-body production may occur. Therefore, there is reason for cautious use of this type of drug irrespective of the age of the patients.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Age Factors
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Aged
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Amdinocillin Pivoxil / administration & dosage
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Amdinocillin Pivoxil / adverse effects*
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Carnitine / blood*
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Carnitine / deficiency
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Female
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Humans
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Male
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Middle Aged
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Norfloxacin / administration & dosage
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Penicillins / administration & dosage
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Penicillins / adverse effects*
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Pentanoic Acids / administration & dosage
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Pentanoic Acids / adverse effects*
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Prodrugs / administration & dosage
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Prodrugs / adverse effects
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Risk Factors
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Time Factors
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Urinary Tract Infections / drug therapy
Substances
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Penicillins
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Pentanoic Acids
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Prodrugs
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Amdinocillin Pivoxil
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pivalic acid
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Norfloxacin
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Carnitine