Abstract
The past two years have seen a significant increase in our understanding of nuclear protein import. Five cytosolic import factors have been identified, two of which have been shown to directly interact with components of the nuclear pore complex. These findings enable refinement of previous models for steps in the nuclear import pathway, and provide a framework for future research.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Biological Transport, Active
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Guanosine Triphosphate / metabolism
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HSP70 Heat-Shock Proteins / metabolism
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Humans
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Ligands
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Models, Biological
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Nuclear Envelope / metabolism
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Nuclear Proteins / metabolism*
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Phosphoproteins / metabolism
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ran GTP-Binding Protein
Substances
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HSP70 Heat-Shock Proteins
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Ligands
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NOLC1 protein, human
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Nuclear Proteins
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Phosphoproteins
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Guanosine Triphosphate
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ran GTP-Binding Protein