A new therapeutic approach for sickle cell disease. Blockade of the red cell Ca(2+)-activated K+ channel by clotrimazole

Ann N Y Acad Sci. 1995 Jul 12:763:262-71. doi: 10.1111/j.1749-6632.1995.tb32411.x.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Administration, Oral
  • Anemia, Sickle Cell / drug therapy*
  • Animals
  • Calcium / metabolism*
  • Clotrimazole / administration & dosage
  • Clotrimazole / pharmacology
  • Clotrimazole / therapeutic use*
  • Disease Models, Animal
  • Erythrocytes / drug effects*
  • Erythrocytes / metabolism
  • Humans
  • Mice
  • Mice, Transgenic
  • Potassium Channel Blockers*
  • Reference Values

Substances

  • Potassium Channel Blockers
  • Clotrimazole
  • Calcium