The production of angiotensinogen is controlled mainly by hormones that affect the concentration of its mRNA in tissues. Accordingly, hormones that act upon gene transcription play a prominent role. However, other factors may modulate the transcriptional effects of hormones, and these should be considered to appreciate the final effects of hormones on the secretion of angiotensinogen. The most important role played by hormones in the regulation of angiotensinogen may be to maintain its production in the face of rapid consumption by high levels of renin. However, elevated levels of angiotensinogen may become a risk factor in situations where the normal feedback regulation of renin does not operate normally. Finally, the synthesis of angiotensinogen in tissues may be regulated differentially than that in liver, although the exact importance of these observations is still poorly understood.