Abstract
Effects of 7-hydroxy-2-(N,N-di-n-propylamino)tetralin (7-OH-DPAT), a dopamine D3-receptor agonist, on neuronal activities of the nucleus accumbens (Acc) were examined in chloral hydrate-anesthetized rats. Spikes elicited by stimulation of the parafascicular nucleus were dose-dependently inhibited by microiontophoretic application of dopamine and 7-OH-DPAT. Glutamate-induced firing was also inhibited by these drugs. These findings suggest that D3 receptors are also involved in the postsynaptic inhibition of Acc neuron by dopamine.
MeSH terms
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Animals
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Benzazepines / pharmacology
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Dopamine Agonists / pharmacology*
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Dose-Response Relationship, Drug
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Drug Interactions
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Electric Stimulation
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Glutamic Acid / toxicity
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Iontophoresis
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Male
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Neurons / drug effects*
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Nucleus Accumbens / cytology
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Nucleus Accumbens / drug effects*
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Rats
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Rats, Wistar
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Receptors, Dopamine / drug effects*
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Receptors, Dopamine D2*
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Receptors, Dopamine D3
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Tetrahydronaphthalenes / pharmacology*
Substances
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Benzazepines
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Dopamine Agonists
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Drd3 protein, rat
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Receptors, Dopamine
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Receptors, Dopamine D2
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Receptors, Dopamine D3
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Tetrahydronaphthalenes
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Glutamic Acid
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7-hydroxy-2-N,N-dipropylaminotetralin