A variety of age-related changes in the blood-brain barrier transport processes have been identified. These include reduced hexose and butyrate transport, reduced choline transport, reduced triiodothyronine transport without a change in the transport of neutral and basic amino acids. The potential mechanisms underlying these age-related changes include hemodynamic alterations in the cerebral circulation of aged rats, notably increased occurrence of arteriovenous shunting. Additional age-related changes in cerebral microvessels include alterations in protein composition, and increased accumulation of lipid peroxidation byproducts, along with changes in membrane fluidity of isolated cerebral microvessels. In addition, neurotransmitter activity notably beta adrenergic neurotransmission, is significantly reduced in cerebral microvessels of aged rats. These alterations taken together may account for some of the age-related changes in the blood-brain barrier.