Multimeric cytokine receptors: common versus specific functions

Curr Opin Cell Biol. 1994 Apr;6(2):174-9. doi: 10.1016/0955-0674(94)90133-3.

Abstract

The class I cytokine receptors consist of multiple subunits without any intrinsic enzymatic activities. Receptors for a subset of cytokines with overlapping biological activities often share a common receptor subunit with a signaling function. Each receptor regulates its specific signaling pathways, as well as common pathways depending on the target cell type.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Animals
  • Humans
  • Interleukin-6 / physiology
  • Macromolecular Substances
  • Models, Structural
  • Receptors, Cytokine / chemistry*
  • Receptors, Cytokine / physiology*
  • Receptors, Interleukin / chemistry
  • Receptors, Interleukin / classification
  • Receptors, Interleukin / physiology
  • Receptors, Interleukin-2 / chemistry
  • Receptors, Interleukin-2 / classification
  • Receptors, Interleukin-2 / physiology
  • Receptors, Interleukin-3 / chemistry
  • Receptors, Interleukin-3 / classification
  • Receptors, Interleukin-3 / physiology
  • Receptors, Interleukin-6
  • Signal Transduction*

Substances

  • Interleukin-6
  • Macromolecular Substances
  • Receptors, Cytokine
  • Receptors, Interleukin
  • Receptors, Interleukin-2
  • Receptors, Interleukin-3
  • Receptors, Interleukin-6