Reduction by Hoe 140, the B2 kinin receptor antagonist, of antigen-induced nasal blockage

Br J Pharmacol. 1994 Apr;111(4):969-71. doi: 10.1111/j.1476-5381.1994.tb14835.x.

Abstract

In subjects with allergic rhinitis to house-dust mite (HDM), antigen challenge produced a significant increase in nasal blockage but had no effect on nasal vascular permeability. The B2 kinin receptor antagonist, [D-Arg0,Hyp3,Thi5,D-Tic7,Oic8]-bradykinin (Hoe 140), 200 micrograms administered by intranasal aerosol 2 min prior to challenge with HDM, 500 u significantly reduced nasal blockage induced by the antigen challenge. The data are compatible with a role for B2 kinin receptors in the nasal response to challenge with antigen which is responsible for nasal blockage.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Antigens / immunology*
  • Bradykinin / analogs & derivatives*
  • Bradykinin / pharmacology
  • Bradykinin Receptor Antagonists*
  • Capillary Permeability
  • Dust
  • Humans
  • Middle Aged
  • Mites / immunology
  • Nose / physiopathology*
  • Receptors, Bradykinin / physiology
  • Rhinitis, Allergic, Seasonal / physiopathology*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Antigens
  • Bradykinin Receptor Antagonists
  • Dust
  • Receptors, Bradykinin
  • icatibant
  • Bradykinin