Abstract
In subjects with allergic rhinitis to house-dust mite (HDM), antigen challenge produced a significant increase in nasal blockage but had no effect on nasal vascular permeability. The B2 kinin receptor antagonist, [D-Arg0,Hyp3,Thi5,D-Tic7,Oic8]-bradykinin (Hoe 140), 200 micrograms administered by intranasal aerosol 2 min prior to challenge with HDM, 500 u significantly reduced nasal blockage induced by the antigen challenge. The data are compatible with a role for B2 kinin receptors in the nasal response to challenge with antigen which is responsible for nasal blockage.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Antigens / immunology*
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Bradykinin / analogs & derivatives*
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Bradykinin / pharmacology
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Bradykinin Receptor Antagonists*
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Capillary Permeability
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Dust
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Humans
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Middle Aged
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Mites / immunology
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Nose / physiopathology*
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Receptors, Bradykinin / physiology
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Rhinitis, Allergic, Seasonal / physiopathology*
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Antigens
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Bradykinin Receptor Antagonists
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Dust
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Receptors, Bradykinin
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icatibant
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Bradykinin