Abstract
We have cloned a cDNA for a novel member of the opioid receptor family, designated as ROR-C, from the rat cerebrum cDNA library using the probe derived from the delta-opioid receptor subtype cDNA. The deduced amino acid sequence of ROR-C shows high homology with those of ROR-A (rat delta-opioid receptor subtype), ROR-B (rat mu-subtype) and ROR-D (rat kappa-subtype). RNA blot hybridization and in situ hybridization analysis revealed that ROR-C mRNA is expressed in discrete regions of the rat central nervous system.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Brain Stem / metabolism
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Cells, Cultured
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Cloning, Molecular
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DNA, Complementary
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Hypothalamus / metabolism
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In Situ Hybridization
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Molecular Sequence Data
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Nuclear Receptor Subfamily 1, Group F, Member 3
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RNA, Messenger / metabolism
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Rats
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Receptors, Opioid / classification
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Receptors, Opioid / genetics*
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Receptors, Opioid / metabolism
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Sequence Homology, Amino Acid
Substances
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DNA, Complementary
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Nuclear Receptor Subfamily 1, Group F, Member 3
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RNA, Messenger
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Receptors, Opioid
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Rorc protein, rat