Objective: To evaluate the progression of hepatic fibrosis in patients with rheumatoid arthritis (RA) treated with methotrexate (MTX).
Methods: Fifteen patients receiving MTX for RA were prospectively studied by electron microscopic analysis of biopsy specimens.
Results: Five of the 15 patients had evidence of increased hepatic collagen after 2 years of MTX therapy.
Conclusion: Hepatic fibrosis may progress in a subgroup of RA patients treated with MTX.