Abstract
Three dopamine receptor mRNAs were detected by reverse polymerase chain reaction in the rat forebrain during ontogeny. The D1 receptor mRNA gave a faint signal from gestational day 11 (G11) on, while the D1b receptor was not detectable before G12. The D3 receptor mRNA was slightly expressed at G11 and clearly present at G14. Our results show that these mRNAs are present at early stages of fetal life, each one with its specific time of appearance.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Animals, Newborn / metabolism
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Animals, Newborn / physiology
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Base Sequence
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Embryo, Mammalian / metabolism
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Embryo, Mammalian / physiology*
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Embryonic and Fetal Development
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Gene Expression*
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Molecular Sequence Data
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Oligonucleotide Probes / genetics
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Polymerase Chain Reaction
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Prosencephalon / embryology*
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RNA, Messenger / metabolism
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Rats / embryology*
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Rats / metabolism
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Rats, Wistar
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Receptors, Dopamine / genetics*
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Receptors, Dopamine D1 / genetics*
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Receptors, Dopamine D2*
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Receptors, Dopamine D3
Substances
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Drd3 protein, rat
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Oligonucleotide Probes
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RNA, Messenger
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Receptors, Dopamine
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Receptors, Dopamine D1
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Receptors, Dopamine D2
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Receptors, Dopamine D3