Abstract
Expression of globin genes in developing erythroid cells is controlled by upstream locus control regions. Activity of these regions in vivo requires an erythroid-specific nuclear factor (NF-E2) that binds AP-1-like recognition sites. Its tissue-specific component (p45 NF-E2) has been characterized by complementary DNA cloning as a new basic region-leucine zipper protein which dimerizes with a ubiquitous partner to form native NF-E2.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Binding Sites
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Cell Line
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Cloning, Molecular
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Consensus Sequence
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DNA / metabolism
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DNA-Binding Proteins / chemistry*
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism
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Erythrocytes / cytology
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Erythrocytes / metabolism*
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Erythroid-Specific DNA-Binding Factors
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Globins / genetics
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Hematopoiesis*
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Leucine Zippers* / genetics
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Leukemia, Erythroblastic, Acute
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Mice
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Molecular Sequence Data
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Mutation
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NF-E2 Transcription Factor
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NF-E2 Transcription Factor, p45 Subunit
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Peptides / genetics
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Peptides / metabolism
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Transcription Factors / chemistry*
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Transcription Factors / genetics
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Transcription Factors / metabolism
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Transfection
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Tumor Cells, Cultured
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Zinc Fingers* / genetics
Substances
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DNA-Binding Proteins
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Erythroid-Specific DNA-Binding Factors
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NF-E2 Transcription Factor
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NF-E2 Transcription Factor, p45 Subunit
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Nfe2 protein, mouse
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Peptides
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Transcription Factors
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Globins
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DNA