Abstract
The frequencies of certain periodic behaviors of the nematode C. elegans are regulated in a dose-dependent manner by the activity of the gene egl-10. These behaviors are modulated oppositely by the activity of the G protein alpha subunit gene goa-1, suggesting that egl-10 may regulate a G protein signaling pathway in a dose-dependent fashion. egl-10 encodes a protein similar to Sst2p, a negative regulator of G protein signaling in yeast. EGL-10 protein is localized in neural processes, where it may function in neurotransmitter signaling. Two previously known and 13 newly identified mammalian genes have similarity to egl-10 and SST2, and we propose that members of this family regulate many G protein signaling pathways.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Alleles
-
Amino Acid Sequence
-
Animals
-
Base Sequence
-
Caenorhabditis elegans / genetics*
-
Caenorhabditis elegans Proteins*
-
Conserved Sequence / physiology
-
Fungal Proteins / genetics
-
GTP-Binding Proteins / analysis
-
GTP-Binding Proteins / genetics*
-
Gene Dosage
-
Genes, Helminth / physiology*
-
Mammals
-
Molecular Sequence Data
-
Muscles / chemistry
-
Muscles / cytology
-
Muscles / physiology
-
Mutation / genetics
-
Nervous System / chemistry
-
Nervous System Physiological Phenomena
-
Ovum / physiology
-
Proteins / genetics
-
Proteins / metabolism*
-
RGS Proteins*
-
Rats
-
Serotonin / metabolism
-
Signal Transduction / genetics
-
Yeasts / genetics
Substances
-
Caenorhabditis elegans Proteins
-
EGL-10 protein, C elegans
-
Fungal Proteins
-
Proteins
-
RGS Proteins
-
Serotonin
-
GTP-Binding Proteins
Associated data
-
GENBANK/U32326
-
GENBANK/U32327
-
GENBANK/U32328
-
GENBANK/U32432
-
GENBANK/U32433
-
GENBANK/U32434
-
GENBANK/U32435
-
GENBANK/U32436
-
GENBANK/U32437
-
GENBANK/U32438
-
GENBANK/U32439