pH-dependent modulation of N-methyl-D-aspartate receptor-mediated synaptic currents by histamine in rat hippocampus in vitro

Neurosci Lett. 1995 Oct 27;199(3):225-7. doi: 10.1016/0304-3940(95)12051-5.

Abstract

Modulation of excitatory postsynaptic currents by histamine was examined using whole cell recording methods in the CA1 region of slices of rat hippocampus. Histamine affected the N-methyl-D-aspartate (NMDA) component of the synaptic current in a pH-dependent manner: at lowered pH (7.2) it enhanced the NMDA-mediated synaptic currents while at raised pH (7.6) it reduced them. At a pH of 7.4 there was no significant action of histamine. Histamine failed to alter the non-NMDA component of the synaptic current. These results indicate that histamine acts at a postsynaptic site to modulate NMDA mediated synaptic currents in a pH dependent manner. This mechanism may have important implications for the pathophysiology of shifts in extracellular pH.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • Evoked Potentials / drug effects
  • Hippocampus / drug effects*
  • Histamine / pharmacology*
  • Hydrogen-Ion Concentration*
  • In Vitro Techniques
  • Presynaptic Terminals / drug effects*
  • Rats
  • Receptors, N-Methyl-D-Aspartate / drug effects*

Substances

  • Receptors, N-Methyl-D-Aspartate
  • Histamine