Abstract
In a variety of vertebrate and invertebrate tissues the ryanodine-sensitive Ca2+ channel is the pathway for Ca2+ release from intracellular stores. The mechanism for activation of the ryanodine receptor-channel complex appears to depend both on the ryanodine receptor isoform and the cell type. In addition, a complex combination of endogenous intracellular compounds regulates channel gating. In this article, Rebecca Sitsapesan, Stephen McGarry and Alan Williams review the mechanisms involved in cyclic ADP-ribose (cADPR)-induced Ca2+ release and discuss the likelihood that cADPR-activated Ca2+ release is mediated by one of the recognized isoforms of the ryanodine receptor-Ca2+ channel complex.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adenosine Diphosphate Ribose / analogs & derivatives*
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Adenosine Diphosphate Ribose / metabolism
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Adenosine Diphosphate Ribose / pharmacology
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Adenosine Triphosphate / metabolism
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Adenosine Triphosphate / pharmacology
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Animals
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Caffeine / metabolism
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Caffeine / pharmacology
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Calcium / metabolism*
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Calcium Channels / drug effects
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Calcium Channels / metabolism*
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Calmodulin / metabolism
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Calmodulin / pharmacology
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Calmodulin-Binding Proteins / drug effects
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Calmodulin-Binding Proteins / metabolism*
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Cyclic ADP-Ribose
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Ion Channel Gating / drug effects*
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Isoenzymes
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Muscle Proteins / drug effects
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Muscle Proteins / metabolism*
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Radioligand Assay
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Ryanodine / metabolism
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Ryanodine / pharmacology
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Ryanodine Receptor Calcium Release Channel
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Sea Urchins
Substances
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Calcium Channels
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Calmodulin
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Calmodulin-Binding Proteins
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Isoenzymes
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Muscle Proteins
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Ryanodine Receptor Calcium Release Channel
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Cyclic ADP-Ribose
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Ryanodine
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Adenosine Diphosphate Ribose
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Caffeine
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Adenosine Triphosphate
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Calcium