Abstract
Tyrosinase is the key enzyme in pigment synthesis, initiating a cascade of reactions which convert the amino acid tyrosine to the melanin biopolymer. Two other tyrosinase-related proteins (TRP) are known, TRP-1 (probably DHICAoxidase) and TRP-2 (DOPAchrome tautomerase). These proteins show about 40% homology, and recent results have indicated that the genes might be derived from a common ancestor. We will discuss recent findings on genomic organization, and on the proteins and their presumed function, which is important for eumelanin synthesis in mouse and man.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Humans
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Intramolecular Oxidoreductases*
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Isomerases / genetics
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Isomerases / metabolism*
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Mammals
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Melanins / biosynthesis*
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Membrane Glycoproteins*
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Mice
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Monophenol Monooxygenase / genetics
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Monophenol Monooxygenase / metabolism*
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Multigene Family
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Oxidoreductases / genetics
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Oxidoreductases / metabolism*
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Pigments, Biological / biosynthesis*
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Proteins*
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Species Specificity
Substances
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Melanins
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Membrane Glycoproteins
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Pigments, Biological
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Proteins
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Oxidoreductases
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TYRP1 protein, human
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Tyrp1 protein, mouse
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tyrosinase-related protein-1
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Monophenol Monooxygenase
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Isomerases
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Intramolecular Oxidoreductases
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dopachrome isomerase