Behavioural effects of the dopamine D3 receptor agonist 7-OH-DPAT in rats

Pharmacol Res. 1995 Jul-Aug;32(1-2):63-8. doi: 10.1016/s1043-6618(95)80010-7.

Abstract

The putative selective dopamine (DA) D3 receptor agonist, 7-OH-DPAT (25-4000 micrograms kg-1), enhanced stretching-yawning and penile erection in male rats, besides respectively increasing and decreasing sedation at low (25-200 micrograms kg-1) and high (1600 and 4000 micrograms kg-1) doses and inducing stereotypy from 800 micrograms kg-1 upwards. The DA D2 antagonist, (-) eticlopride (10 and 20 micrograms kg-1), antagonized stretching-yawning and penile erection induced by a low dose of 7-OH-DPAT (50 micrograms kg-1) but not those produced by high doses (1600 and 4000 micrograms kg-1), when stereotyped behaviour, on the other hand, was potently inhibited. Comparative experiments performed with the DA agonist SND 919 gave similar results.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Behavior, Animal / drug effects*
  • Benzothiazoles
  • Dopamine Agonists / pharmacology*
  • Male
  • Motor Activity / drug effects
  • Penile Erection
  • Pramipexole
  • Rats
  • Salicylamides / pharmacology
  • Tetrahydronaphthalenes / pharmacology*
  • Thiazoles / pharmacology*

Substances

  • Benzothiazoles
  • Dopamine Agonists
  • Salicylamides
  • Tetrahydronaphthalenes
  • Thiazoles
  • Pramipexole
  • eticlopride
  • 7-hydroxy-2-N,N-dipropylaminotetralin