Abstract
The cytokines interleukin-1 and tumor necrosis factor contribute to the pathogenesis of inflammatory diseases and, potentially, to atherogenesis. The synthesis of these cytokines in humans can be suppressed by oral intake of n-3 polyunsaturated fatty acids. This mechanism may contribute to the beneficial effect of long-term n-3 fatty acid supplementation in inflammatory diseases such as renal transplant rejection, immunoglobulin A nephropathy and rheumatoid arthritis.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Arthritis, Rheumatoid / drug therapy
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Arthritis, Rheumatoid / etiology
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Clinical Trials as Topic
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Cytokines / biosynthesis*
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Fatty Acids, Omega-3 / metabolism*
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Fatty Acids, Omega-3 / pharmacology
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Fatty Acids, Omega-3 / therapeutic use
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Graft Rejection / drug therapy
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Humans
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Interleukin-1 / biosynthesis
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Multiple Sclerosis / drug therapy
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Multiple Sclerosis / etiology
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Tumor Necrosis Factor-alpha / biosynthesis
Substances
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Cytokines
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Fatty Acids, Omega-3
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Interleukin-1
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Tumor Necrosis Factor-alpha