Abstract
The effects of a 7-day administration of neuromedin B (NMB) and/or (Tyr4, D-Phe12)-bombesin, an NMB-receptor antagonist (NMB-A) on the function of pituitary-adrenocortical axis were investigated in the rat. NMB raised the plasma concentration of aldosterone, without affecting that of ACTH or corticosterone; the simultaneous administration of NMB-A prevented the effect of NMB. Neither NMB nor NMB-A treatments induced significant changes in adenohypophysis and adrenal weights, nor in the average volume of zona glomerulosa and zona reticularis cells. NMB-A administration lowered the volume of zona fasciculata cells, an effect annulled by the concomitant NMB administration. Our results suggest that NMB specifically stimulates aldosterone secretion, and that endogenous NMB or NMB-like peptides exert a tonic stimulating action on the growth of zona fasciculata cells.
MeSH terms
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Adrenal Cortex / cytology
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Adrenal Cortex / drug effects
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Adrenal Cortex / physiology*
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Adrenocorticotropic Hormone / blood
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Adrenocorticotropic Hormone / metabolism*
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Animals
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Bombesin / analogs & derivatives
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Bombesin / pharmacology
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Corticosterone / blood
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Corticosterone / metabolism*
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Female
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Neurokinin B / analogs & derivatives*
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Neurokinin B / pharmacology
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Organ Size / drug effects
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Pituitary Gland, Anterior / cytology
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Pituitary Gland, Anterior / drug effects
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Pituitary Gland, Anterior / physiology*
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Pituitary-Adrenal System / drug effects
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Pituitary-Adrenal System / physiology*
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Rats
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Rats, Wistar
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Receptors, Bombesin / antagonists & inhibitors
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Time Factors
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Zona Glomerulosa / anatomy & histology
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Zona Glomerulosa / cytology
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Zona Glomerulosa / drug effects
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Zona Reticularis / anatomy & histology
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Zona Reticularis / cytology
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Zona Reticularis / drug effects
Substances
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Receptors, Bombesin
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bombesin, Tyr(4), Phe(12)-
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Neurokinin B
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neuromedin B
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Adrenocorticotropic Hormone
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Bombesin
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Corticosterone