(S)-(+)-4-[7-(2,2-dimethyl-1-oxopropoxy)-4-methyl-2-[4-[2-(1-piperidinyl)-ethoxy]phenyl]-2H-1-benzopyran-3-yl]-phenyl 2,2-dimethylpropanoate (EM-800): a highly potent, specific, and orally active nonsteroidal antiestrogen

J Med Chem. 1997 Jul 4;40(14):2117-22. doi: 10.1021/jm970095o.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Animals
  • Benzopyrans / chemical synthesis*
  • Benzopyrans / chemistry
  • Benzopyrans / pharmacology
  • Binding, Competitive
  • Breast Neoplasms / metabolism*
  • Cytosol / metabolism
  • Diethylstilbestrol / metabolism
  • Estradiol / metabolism
  • Estrogen Antagonists / chemical synthesis*
  • Estrogen Antagonists / chemistry
  • Estrogen Antagonists / pharmacology
  • Female
  • Humans
  • Mice
  • Molecular Structure
  • Ovariectomy
  • Piperidines / chemistry
  • Propionates / chemical synthesis*
  • Propionates / chemistry
  • Propionates / pharmacology
  • Raloxifene Hydrochloride
  • Receptors, Estrogen / metabolism*
  • Stereoisomerism
  • Structure-Activity Relationship
  • Uterus / drug effects
  • Uterus / metabolism*

Substances

  • Benzopyrans
  • Estrogen Antagonists
  • Piperidines
  • Propionates
  • Receptors, Estrogen
  • Raloxifene Hydrochloride
  • Estradiol
  • Diethylstilbestrol
  • EM 800