Vasoconstrictor effect of midodrine, ST 1059, noradrenaline, etilefrine and dihydroergotamine on isolated human veins

Eur J Clin Pharmacol. 1979;16(6):423-4. doi: 10.1007/BF00568204.

Abstract

ST 1059, the pharmacologically active metabolite of midodrine, is a powerful vasoconstrictor compound, acting by stimulation of alpha-receptors. It elicited 80% of noradrenaline-induced contraction of human veins.

Publication types

  • Comparative Study

MeSH terms

  • Dihydroergotamine / pharmacology*
  • Ethanolamines / pharmacology*
  • Etilefrine / pharmacology*
  • Humans
  • In Vitro Techniques
  • Midodrine / analogs & derivatives
  • Midodrine / pharmacology*
  • Muscle, Smooth, Vascular / drug effects
  • Norepinephrine / pharmacology*
  • Phenylephrine / analogs & derivatives*
  • Vasoconstrictor Agents*
  • Veins / drug effects

Substances

  • Ethanolamines
  • Vasoconstrictor Agents
  • Phenylephrine
  • ST 1059
  • Dihydroergotamine
  • Midodrine
  • Norepinephrine
  • Etilefrine