Active efflux by multidrug transporters as one of the strategies to evade chemotherapy and novel practical implications of yeast pleiotropic drug resistance

M Kolaczkowski; A Goffeau

doi:10.1016/s0163-7258(97)00094-6

Active efflux by multidrug transporters as one of the strategies to evade chemotherapy and novel practical implications of yeast pleiotropic drug resistance

Pharmacol Ther. 1997 Oct-Dec;76(1-3):219-42. doi: 10.1016/s0163-7258(97)00094-6.

Authors

M Kolaczkowski¹, A Goffeau

Affiliation

¹ Unité de Biochimie Physiologique, Université Catholique de Louvain, Louvain La Neuve, Belgium.

PMID: 9535181
DOI: 10.1016/s0163-7258(97)00094-6

Abstract

Mankind is faced by the increasing emergence of resistant pathogens, including cancer cells. An overview of the different strategies adopted by a variety of cells to evade chemotherapy is presented, with a focus on the mechanisms of multidrug transport. In particular, we analyze the yeast network for pleiotropic drug resistance and assess the potentiality of this system for further understanding of the mechanism of broad specificity and for development of novel practical applications.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

ATP-Binding Cassette Transporters / metabolism*
Animals
Antifungal Agents / pharmacology
Antineoplastic Agents / administration & dosage
Antineoplastic Agents / pharmacokinetics
Drug Resistance, Microbial*
Drug Resistance, Multiple*
Humans
Phenotype
Saccharomyces cerevisiae / drug effects*
Saccharomyces cerevisiae / genetics

Substances

ATP-Binding Cassette Transporters
Antifungal Agents
Antineoplastic Agents