Epolones: novel sesquiterpene-tropolones from fungus OS-F69284 that induce erythropoietin in human cells

P Cai; D Smith; B Cunningham; S Brown-Shimer; B Katz; C Pearce; D Venables; D Houck

doi:10.1021/np9800506

Epolones: novel sesquiterpene-tropolones from fungus OS-F69284 that induce erythropoietin in human cells

J Nat Prod. 1998 Jun 26;61(6):791-5. doi: 10.1021/np9800506.

Authors

P Cai¹, D Smith, B Cunningham, S Brown-Shimer, B Katz, C Pearce, D Venables, D Houck

Affiliation

¹ MYCOsearch, a subsidiary of OSI Pharmaceuticals, 4727 University Drive, Suite 400, Durham, North Carolina 27707, USA.

PMID: 9644066
DOI: 10.1021/np9800506

Abstract

In the course of our screening for small molecule modulators of erythropoietin gene expression, two novel sesquiterpene tropolones and pycnidone were isolated from a culture of OS-F69284 (ATCC 74390). Their structures were elucidated by extensive 1H and 13C NMR spectroscopic studies and chemical reactions. These compounds induced erythropoietin gene expression 5-fold at a concentration of 1-1.6 microM.

MeSH terms

Carbohydrate Sequence
Cell Line
Erythropoietin / biosynthesis*
Fungi / chemistry*
Gene Expression / drug effects*
Humans
Magnetic Resonance Spectroscopy
Mass Spectrometry
Methylation
Molecular Conformation
Molecular Sequence Data
Sesquiterpenes / isolation & purification*
Sesquiterpenes / pharmacology
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet

Substances

Sesquiterpenes
Erythropoietin