Discovery of a novel, potent, and orally active nonpeptide antagonist of the human luteinizing hormone-releasing hormone (LHRH) receptor

MeSH terms

• Animals
• CHO Cells
• Cloning, Molecular
• Cricetinae
• Humans
• In Vitro Techniques
• Luteinizing Hormone / antagonists & inhibitors
• Luteinizing Hormone / blood
• Macaca fascicularis
• Male
• Models, Molecular
• Pituitary Gland, Anterior / cytology
• Pituitary Gland, Anterior / drug effects
• Pituitary Gland, Anterior / metabolism
• Pyridones / chemical synthesis*
• Pyridones / chemistry
• Pyridones / pharmacology
• Rats
• Rats, Wistar
• Receptors, LHRH / antagonists & inhibitors*
• Receptors, LHRH / biosynthesis
• Thiophenes / chemical synthesis*
• Thiophenes / chemistry
• Thiophenes / pharmacology