Pharmacology and Therapeutic Potential of Benzothiazole Analogues for Cocaine Use Disorder.
Boateng CA, Nilson AN, Placide R, Pham ML, Jakobs FM, Boldizsar N, McIntosh S, Stallings LS, Korankyi IV, Kelshikar S, Shah N, Panasis D, Muccilli A, Ladik M, Maslonka B, McBride C, Sanchez MX, Akca E, Alkhatib M, Saez J, Nguyen C, Kurtyan E, DePierro J, Crowthers R, Brunt D, Bonifazi A, Newman AH, Rais R, Slusher BS, Free RB, Sibley DR, Stewart KD, Wu C, Hemby SE, Keck TM.
Boateng CA, et al. Among authors: sibley dr.
J Med Chem. 2023 Sep 14;66(17):12141-12162. doi: 10.1021/acs.jmedchem.3c00734. Epub 2023 Aug 30.
J Med Chem. 2023.
PMID: 37646374
Free PMC article.
This study focused on the synthesis and evaluation of a novel series of benzothiazole analogues designed to target D(4)R. We identified several compounds with high D(4)R binding affinity (K(i) 6.9 nM) and >91-fold selectivity over other D(2)-like receptors (D(2) …
This study focused on the synthesis and evaluation of a novel series of benzothiazole analogues designed to target D(4)R. We identifi …