Polymorphic variants of adrenoceptors: pharmacology, physiology, and role in disease

A Ahles, S Engelhardt - Pharmacological reviews, 2014 - ASPET
The human genome encodes nine different adrenoceptor genes. These are grouped into
three families, namely, the α 1 -, α 2 -, and β-adrenoceptors, with three family members each. …

MiR-378 controls cardiac hypertrophy by combined repression of mitogen-activated protein kinase pathway factors

J Ganesan, D Ramanujam, Y Sassi, A Ahles… - Circulation, 2013 - Am Heart Assoc
Background— Several microRNAs (miRs) have been shown to regulate gene expression in
the heart, and dysregulation of their expression has been linked to cardiac disease. miR-…

Immune-mediated denervation of the pineal gland underlies sleep disturbance in cardiac disease

KA Ziegler, A Ahles, A Dueck, D Esfandyari, P Pichler… - Science, 2023 - science.org
Disruption of the physiologic sleep-wake cycle and low melatonin levels frequently accompany
cardiac disease, yet the underlying mechanism has remained enigmatic. Immunostaining …

[HTML][HTML] Cancer-and cancer treatment–associated cognitive change: an update on the state of the science

TA Ahles, JC Root, EL Ryan - Journal of Clinical Oncology, 2012 - ncbi.nlm.nih.gov
Cognitive changes associated with cancer and cancer treatments have become an
increasing concern. Using breast cancer as the prototype, we reviewed the research from …

Cognitive impairment associated with chemotherapy for cancer: report of a workshop

IF Tannock, TA Ahles, PA Ganz… - Journal of Clinical …, 2004 - ascopubs.org
Cognitive dysfunction may occur in some patients who receive chemotherapy. We provide a
summary of an April 2003 workshop on this topic, that included medical oncologists, …

[HTML][HTML] i is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling

…, MA Makara, GR Dahal, Q Chen, A Ahles… - Nature …, 2017 - nature.com
The β 1 adrenergic receptor (β 1 AR) is recognized as a classical Gα s -coupled receptor.
Agonist binding not only initiates G protein-mediated signaling but also signaling through the …

[PDF][PDF] Branch-specific microtubule destabilization mediates axon branch loss during neuromuscular synapse elimination

…, MS Reuter, TJ Hausrat, E Weigand, M Fisher, A Ahles… - Neuron, 2016 - cell.com
Developmental axon remodeling is characterized by the selective removal of branches from
axon arbors. The mechanisms that underlie such branch loss are largely unknown. …

[HTML][HTML] Cardiac myocyte–secreted cAMP exerts paracrine action via adenosine receptor activation

Y Sassi, A Ahles, DJJ Truong, Y Baqi… - The Journal of …, 2014 - Am Soc Clin Investig
Acute stimulation of cardiac β-adrenoceptors is crucial to increasing cardiac function under
stress; however, sustained β-adrenergic stimulation has been implicated in pathological …

Local sympathetic denervation attenuates myocardial inflammation and improves cardiac function after myocardial infarction in mice

KA Ziegler, A Ahles, T Wille, J Kerler… - Cardiovascular …, 2018 - academic.oup.com
Aims Cardiac inflammation has been suggested to be regulated by the sympathetic nervous
system (SNS). However, due to the lack of methodology to surgically eliminate the …

Effects of a palliative care intervention on clinical outcomes in patients with advanced cancer: the Project ENABLE II randomized controlled trial

…, JG Hull, Z Li, TD Tosteson, IR Byock, TA Ahles - Jama, 2009 - jamanetwork.com
Context There are few randomized controlled trials on the effectiveness of palliative care
interventions to improve the care of patients with advanced cancer. Objective To determine the …