Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ

A Inui, A Asakawa, C Y. Bowers… - The FASEB …, 2004 - Wiley Online Library
Recent progress in the field of energy homeostasis was triggered by the discovery of
adipocyte hormone leptin and revealed a complex regulatory neuroendocrine network. A late …

[HTML][HTML] Cancer cachexia—pathophysiology and management

H Suzuki, A Asakawa, H Amitani, N Nakamura… - Journal of …, 2013 - Springer
About half of all cancer patients show a syndrome of cachexia, characterized by anorexia and
loss of adipose tissue and skeletal muscle mass. Cachexia can have a profound impact on …

Ghrelin gene products and the regulation of food intake and gut motility

CY Chen, A Asakawa, M Fujimiya, SD Lee… - Pharmacological reviews, 2009 - ASPET
A breakthrough using “reverse pharmacology” identified and characterized acyl ghrelin from
the stomach as the endogenous cognate ligand for the growth hormone (GH) secretagogue …

Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin

A Asakawa, A Inui, O Kaga, H Yuzuriha, T Nagata… - Gastroenterology, 2001 - Elsevier
Background & Aims: Ghrelin, an endogenous ligand for growth hormone secretagogue
receptor, was recently identified in the rat stomach. We examined the effects of the gastric …

Antagonism of ghrelin receptor reduces food intake and body weight gain in mice

A Asakawa, A Inui, T Kaga, G Katsuura, M Fujimiya… - Gut, 2003 - gut.bmj.com
Background and aims: Ghrelin, an endogenous ligand for growth hormone secretagogue
receptor (GHS-R), is an appetite stimulatory signal from the stomach with structural …

Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin

A Asakawa, A Inui, M Fujimiya, R Sakamaki… - Gut, 2005 - gut.bmj.com
Background/Aims: The gastric peptide ghrelin, an endogenous ligand for growth-hormone
secretagogue receptor, has two major molecular forms: acylated ghrelin and desacyl ghrelin. …

Characterization of the effects of pancreatic polypeptide in the regulation of energy balance

A Asakawa, A Inui, H Yuzuriha, N Ueno, G Katsuura… - Gastroenterology, 2003 - Elsevier
BACKGROUND & AIMS:: Pancreatic polypeptide (PP) belongs to a family of peptides including
neuropeptide Y and peptide YY. We examined the role of PP in the regulation of body …

Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats

K Fujino, A Inui, A Asakawa, N Kihara… - The Journal of …, 2003 - Wiley Online Library
Ghrelin is a newly discovered orexigenic peptide originating from the stomach. However, its
action in regulating the fed and fasted motor activity of the digestive tract is not fully …

[PDF][PDF] Role of hepatic STAT3 in brain-insulin action on hepatic glucose production

H Inoue, W Ogawa, A Asakawa, Y Okamoto… - Cell metabolism, 2006 - cell.com
STAT3 regulates glucose homeostasis by suppressing the expression of gluconeogenic
genes in the liver. The mechanism by which hepatic STAT3 is regulated by nutritional or …

[HTML][HTML] The role of leptin in the control of insulin-glucose axis

M Amitani, A Asakawa, H Amitani, A Inui - Frontiers in neuroscience, 2013 - frontiersin.org
Obesity and diabetes mellitus are great public health concerns throughout the world because
of their increasing incidence and prevalence. Leptin, the adipocyte hormone, is well known …