Chitosans as absorption enhancers for poorly absorbable drugs 2: mechanism of absorption enhancement

…, S Olsson, JA Hoogstraate, AG deBoer… - Pharmaceutical …, 1997 - Springer
Purpose. It has recently been shown that the absorption enhancing and toxic effects of chitosans
are dependent on their chemical composition. In this study, the mechanisms underlying …

The blood-brain barrier in neuroinflammatory diseases

HE De Vries, J Kuiper, AG De Boer… - Pharmacological …, 1997 - ASPET
The existence of the blood-brain barrier (BBB) b was revealed through studies by Ehrlich (1885)
in the late 19th century, describing that brain tissue remained unstained after injection of …

The potential of mucoadhesive polymers in enhancing intestinal peptide drug absorption. III: Effects of chitosan-glutamate and carbomer on epithelial tight junctions in …

G Borchard, HL Lueβen, AG de Boer… - Journal of controlled …, 1996 - Elsevier
Two mucoadhesive polymers, chitosan-glutamate and carbomer, were studied in an in vitro
model (Caco-2 cell monolayers) with respect to their ability to enhance intestinal peptide …

Methodological considerations of intracerebral microdialysis in pharmacokinetic studies on drug transport across the blood–brain barrier

ECM de Lange, M Danhof, AG de Boer… - Brain research reviews, 1997 - Elsevier
For the study of the pharmacokinetics of drugs in the brain a number of in vivo techniques is
available, including autoradiography, imaging techniques, cerebrospinal fluid sampling and …

Pharmacokinetics of rectal drug administration, part I: general considerations and clinical applications of centrally acting drugs

EJ van Hoogdalem, AG de Boer, DD Breimer - Clinical pharmacokinetics, 1991 - Springer
Generally, oral administration is the route of choice in the daily practice of pharmacotherapy.
However, in some circumstances this is impractical or even impossible (during nausea and …

The role of P‐glycoprotein in blood‐brain barrier transport of morphine: transcortical microdialysis studies in mdr1a (−/−) and mdr1a (+/+) mice

…, AG De Boer, ECM De Lange - British journal of …, 1999 - Wiley Online Library
The aim of this study was to investigate whether blood‐brain barrier transport of morphine
was affected by the absence of mdr1a‐encoded P‐glycoprotein (Pgp), by comparing mdr1a (−/…

Targeted delivery across the blood–brain barrier

PJ Gaillard, CC Visser, AG de Boer - Expert opinion on drug …, 2005 - Taylor & Francis
The safest and most effective way of targeting drugs to the entire brain is via delivery systems
directed at endogenous receptor-mediated uptake mechanisms present at the cerebral …

Targeting liposomes with protein drugs to the blood–brain barrier in vitro

…, M Danhof, DJA Crommelin, AG de Boer - European journal of …, 2005 - Elsevier
In this study, we aim to target pegylated liposomes loaded with horseradish peroxidase (HRP)
and tagged with transferrin (Tf) to the BBB in vitro. Liposomes were prepared with the post-…

Bioadhesion by means of specific binding of tomato lectin

…, JA Bouwstra, W Kok, ABJ Noach, AG de Boer… - Pharmaceutical …, 1992 - Springer
The possibility of developing bioadhesive drug delivery systems on the basis of molecules
which selectively bind to the small intestinal epithelium by specific, receptor-mediated …

Diphtheria toxin receptor-targeted brain drug delivery

PJ Gaillard, A Brink, AG De Boer - International Congress Series, 2005 - Elsevier
Brain drug delivery is limited by the blood–brain barrier (BBB). We have newly identified the
membrane-bound precursor of heparin-binding epidermal growth factor (HB-EGF), which is …