The physiology, pathology, and pharmacology of voltage-gated calcium channels and their future therapeutic potential
GW Zamponi, J Striessnig, A Koschak… - Pharmacological …, 2015 - ASPET
Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …
review, the different subtypes of voltage-gated calcium channels are described and their …
[HTML][HTML] α1D (Cav1. 3) subunits can form L-type Ca2+ channels activating at negative voltages
A Koschak, D Reimer, I Huber, M Grabner… - Journal of Biological …, 2001 - ASBMB
In cochlea inner hair cells (IHCs), L-type Ca 2+ channels (LTCCs) formed by α1D subunits (D-LTCCs)
possess biophysical and pharmacological properties distinct from those of α1C …
possess biophysical and pharmacological properties distinct from those of α1C …
Loss of Cav1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafness
SM Baig, A Koschak, A Lieb, M Gebhart… - Nature …, 2011 - nature.com
Deafness is genetically very heterogeneous and forms part of several syndromes. So far,
delayed rectifier potassium channels have been linked to human deafness associated with …
delayed rectifier potassium channels have been linked to human deafness associated with …
[HTML][HTML] Isoform-specific regulation of mood behavior and pancreatic β cell and cardiovascular function by L-type Ca2+ channels
…, M Cavalli, D Walter, A Koschak… - The Journal of …, 2004 - Am Soc Clin Investig
Ca v 1.2 and Ca v 1.3 L-type Ca 2+ channels (LTCCs) are believed to underlie Ca 2+ currents
in brain, pancreatic β cells, and the cardiovascular system. In the CNS, neuronal LTCCs …
in brain, pancreatic β cells, and the cardiovascular system. In the CNS, neuronal LTCCs …
Expression and 1, 4-dihydropyridine-binding properties of brain L-type calcium channel isoforms
MJ Sinnegger-Brauns, IG Huber, A Koschak… - Molecular …, 2009 - ASPET
The L-type calcium channel (LTCC) isoforms Ca v 1.2 and Ca v 1.3 display similar 1,4-dihydropyridine
(DHP) binding properties and are both expressed in mammalian brain. Recent …
(DHP) binding properties and are both expressed in mammalian brain. Recent …
[HTML][HTML] Modulation of voltage-and Ca2+-dependent gating of CaV1. 3 L-type calcium channels by alternative splicing of a C-terminal regulatory domain
…, J Engel, C Romanin, J Striessnig, A Koschak - Journal of biological …, 2008 - ASBMB
Low voltage activation of Ca V 1.3 L-type Ca 2+ channels controls excitability in sensory
cells and central neurons as well as sinoatrial node pacemaking. Ca V 1.3-mediated …
cells and central neurons as well as sinoatrial node pacemaking. Ca V 1.3-mediated …
[HTML][HTML] Channelopathies in Cav1.1, Cav1.3, and Cav1.4 voltage-gated L-type Ca2+ channels
J Striessnig, HJ Bolz, A Koschak - Pflügers Archiv-European Journal of …, 2010 - Springer
Voltage-gated Ca 2+ channels couple membrane depolarization to Ca 2+ -dependent
intracellular signaling events. This is achieved by mediating Ca 2+ ion influx or by direct …
intracellular signaling events. This is achieved by mediating Ca 2+ ion influx or by direct …
C-terminal modulator controls Ca2+-dependent gating of Cav1.4 L-type Ca2+ channels
…, D Hamedinger, JC Hoda, M Gebhart, A Koschak… - Nature …, 2006 - nature.com
Tonic neurotransmitter release at sensory cell ribbon synapses is mediated by calcium (Ca 2+
) influx through L-type voltage-gated Ca 2+ channels. This tonic release requires the …
) influx through L-type voltage-gated Ca 2+ channels. This tonic release requires the …
[HTML][HTML] Functional properties of a newly identified C-terminal splice variant of Cav1. 3 L-type Ca2+ channels
…, S Herzig, J Striessnig, A Koschak - Journal of Biological …, 2011 - ASBMB
An intramolecular interaction between a distal (DCRD) and a proximal regulatory domain (PCRD)
within the C terminus of long Ca v 1.3 L-type Ca 2+ channels (Ca v 1.3 L ) is a major …
within the C terminus of long Ca v 1.3 L-type Ca 2+ channels (Ca v 1.3 L ) is a major …
Cav1. 4α1 subunits can form slowly inactivating dihydropyridine-sensitive L-type Ca2+ channels lacking Ca2+-dependent inactivation
A Koschak, D Reimer, D Walter, JC Hoda… - Journal of …, 2003 - Soc Neuroscience
The neuronal L-type calcium channels (LTCCs) Ca v 1.2α1 and Ca v 1.3α1 are functionally
distinct. Ca v 1.3α1 activates at lower voltages and inactivates more slowly than Ca v 1.2α1, …
distinct. Ca v 1.3α1 activates at lower voltages and inactivates more slowly than Ca v 1.2α1, …