Chemerin, a chemoattractant protein and adipokine, has been identified as the endogenous
ligand for a G protein–coupled receptor encoded by the gene CMKLR1 (also known as …

Background Circulating levels of chemerin are significantly higher in hypertensive patients
and positively correlate with blood pressure. Chemerin activates chemokine‐like receptor 1 ( …

Protease-activated receptor-2 (PAR2) has been implicated in multiple pathophysiologies
but drug discovery is challenging due to low small molecule tractability and a complex …

Sphingolipids (SLs) are ubiquitous elements in eukaryotic membranes and are also found in
some bacterial and viral species. As well as playing an integral structural role, SLs also act …

Protease-activated receptor 2 (PAR2) is a G-protein-coupled receptor that is activated by
proteolytic cleavage of its N-terminus. The unmasked N-terminal peptide then binds to the …

Schizophrenia is a complex psychiatric disorder where genetic, epigenetic, and environmental
factors play a role in disease onset, course of illness, and treatment outcome. Pharmaco(…

Antidepressant medications are the most common treatment for major depression and
related disorders. Pharmacogenetic studies have demonstrated that response to these …

Sphingolipids (SLs) are ubiquitous elements in eukaryotic membranes and are also found in
some bacterial and viral species. As well as playing an integral structural role, SLs also act …

Generalized anxiety disorder (GAD) is a prevalent and chronic mental disorder that elicits
widespread functional impairment. Given the high degree of non-response/partial response …

Purposes/Background: Antidepressants (ADs) play a valuable role in treating the depressive
episodes of bipolar disorder. However, 14% of these individuals taking ADs experience AD-…