The prefrontal cortex guides behaviors, thoughts, and feelings using representational
knowledge, ie, working memory. These fundamental cognitive abilities subserve the so-called …

The symptoms of attention-deficit/hyperactivity disorder (ADHD) involve impairments in
prefrontal cortical top-down regulation of attention and behavior. All current pharmacological …

Dopamine (DA) D1 receptor (D1R) stimulation in prefrontal cortex (PFC) produces an 'inverted-U'
dose-response, whereby either too little or too much D1R stimulation impairs spatial …

Although previous research has emphasized the beneficial effects of dopamine (DA) on
functions of the prefrontal cortex (PFC), recent studies of animals exposed to mild stress indicate …

Background Stress can exacerbate a number of psychiatric disorders, many of which are
associated with prefrontal cortical (PFC) cognitive deficits. Biochemical studies demonstrate …

OBJECTIVE: This article aims to review basic and clinical studies outlining the roles of prefrontal
cortical (PFC) networks in the behavior and cognitive functions that are compromised in …

This review describes unique neuromodulatory influences on working memory prefrontal
cortical (PFC) circuits that coordinate cognitive strength with arousal state. Working memory …

The prefrontal cortex (PFC) — the most evolved brain region — subserves our highest-order
cognitive abilities. However, it is also the brain region that is most sensitive to the …

A variety of cognitive disorders are worsened by stress exposure and involve dysfunction of
the newly evolved prefrontal cortex (PFC). Exposure to acute, uncontrollable stress …

Norepinephrine (NE) has widespread projections throughout the brain, and thus, is ideally
positioned to orchestrate neural functions based on arousal state. For example, NE can …