The role of the anaphylatoxins in health and disease
A Klos, AJ Tenner, KO Johswich, RR Ager, ES Reis… - Molecular …, 2009 - Elsevier
The anaphylatoxin (AT) C3a, C5a and C5a-desArg are generally considered pro-inflammatory
polypeptides generated after proteolytic cleavage of C3 and C5 in response to …
polypeptides generated after proteolytic cleavage of C3 and C5 in response to …
Molecular intercommunication between the complement and coagulation systems
U Amara, MA Flierl, D Rittirsch, A Klos… - The Journal of …, 2010 - journals.aai.org
The complement system as well as the coagulation system has fundamental clinical implications
in the context of life-threatening tissue injury and inflammation. Associations between …
in the context of life-threatening tissue injury and inflammation. Associations between …
Interaction between the coagulation and complement system
…, D Rittirsch, M Flierl, U Bruckner, A Klos… - Current topics in …, 2008 - Springer
The complement system as a main column of innate immunity and the coagulation system
as a main column in hemostasis undergo massive activation early after injury. Interactions …
as a main column in hemostasis undergo massive activation early after injury. Interactions …
T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells
G Arbore, EE West, R Spolski, AAB Robertson, A Klos… - Science, 2016 - science.org
INTRODUCTION The inflammasomes and the complement system are traditionally viewed
as quintessential components of innate immunity required for the detection and elimination of …
as quintessential components of innate immunity required for the detection and elimination of …
Discrimination of sepsis and systemic inflammatory response syndrome by determination of circulating plasma concentrations of procalcitonin, protein complement 3a …
O Selberg, H Hecker, M Martin, A Klos… - Critical care …, 2000 - journals.lww.com
Objective To evaluate whether plasma concentrations of procalcitonin (PCT), interleukin-6 (IL-6),
protein complement 3a (C3a), leukocyte elastase (elastase), and the C-reactive protein …
protein complement 3a (C3a), leukocyte elastase (elastase), and the C-reactive protein …
International union of basic and clinical pharmacology. LXXXVII. Complement peptide C5a, C4a, and C3a receptors
A Klos, E Wende, KJ Wareham, PN Monk - Pharmacological reviews, 2013 - ASPET
The activation of the complement cascade, a cornerstone of the innate immune response,
produces a number of small (74–77 amino acid) fragments, originally termed anaphylatoxins, …
produces a number of small (74–77 amino acid) fragments, originally termed anaphylatoxins, …
Chlamydia Inhibit Host Cell Apoptosis by Degradation of Proapoptotic BH3-only Proteins
SF Fischer, J Vier, S Kirschnek, A Klos… - The Journal of …, 2004 - rupress.org
Chlamydia are obligate intracellular bacteria that replicate in a vacuole inside a host cell.
Chlamydial infection has been shown to protect the host cell against apoptotic stimuli. This is …
Chlamydial infection has been shown to protect the host cell against apoptotic stimuli. This is …
Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models
…, W Bautsch, B Settmacher, A Klos… - The Journal of …, 2001 - journals.aai.org
The anaphylatoxin C3a is a potent chemotactic peptide and inflammatory mediator released
during complement activation which binds to and activates a G-protein-coupled receptor. …
during complement activation which binds to and activates a G-protein-coupled receptor. …
[HTML][HTML] The human complement fragment receptor, C5L2, is a recycling decoy receptor
AM Scola, KO Johswich, BP Morgan, A Klos… - Molecular …, 2009 - Elsevier
C5L2 is a 7 transmembrane domain receptor for complement fragment C5a that, unlike the
classical C5a receptor, C5aR, does not couple to G proteins. However, in mice where C5L2 …
classical C5a receptor, C5aR, does not couple to G proteins. However, in mice where C5L2 …
The human C3a receptor is expressed on neutrophils and monocytes, but not on B or T lymphocytes
…, W Bautsch, J Köhl, A Ganser, A Klos - The Journal of …, 1997 - rupress.org
The pathophysiological relevance of the complement split product C3a as a proinflammatory
mediator is still ill defined. The expression pattern of the human C3a receptor (C3aR) can …
mediator is still ill defined. The expression pattern of the human C3a receptor (C3aR) can …