The pharmacology and clinical pharmacology of 3, 4-methylenedioxymethamphetamine (MDMA,“ecstasy”)
AR Green, AO Mechan, JM Elliott, E O'Shea… - Pharmacological …, 2003 - ASPET
The amphetamine derivative (±)-3,4-methylenedioxymethamphetamine (MDMA, ecstasy) is
a popular recreational drug among young people, particularly those involved in the dance …
a popular recreational drug among young people, particularly those involved in the dance …
The pharmacology of the acute hyperthermic response that follows administration of 3, 4‐methylenedioxymethamphetamine (MDMA,'ecstasy') to rats
AO Mechan, B Esteban, E O'Shea… - British journal of …, 2002 - Wiley Online Library
The pharmacology of the acute hyperthermia that follows 3,4‐methylenedioxymethamphetamine
(MDMA, ‘ecstasy’) administration to rats has been investigated. MDMA (12.5 mg kg −1 …
(MDMA, ‘ecstasy’) administration to rats has been investigated. MDMA (12.5 mg kg −1 …
A comparison between Dark Agouti and Sprague-Dawley rats in their behaviour on the elevated plus-maze, open-field apparatus and activity meters, and their …
AO Mechan, PM Moran, MJ Elliott, AM Young… - …, 2002 - Springer
Rationale: Preliminary unpublished studies in our laboratory suggested that the behaviour
of Sprague-Dawley (SD) and Dark Agouti (DA) rats was markedly different on both the …
of Sprague-Dawley (SD) and Dark Agouti (DA) rats was markedly different on both the …
A study of the mechanisms involved in the neurotoxic action of 3, 4‐methylenedioxymethamphetamine (MDMA,'ecstasy') on dopamine neurones in mouse brain
MI Colado, J Camarero, AO Mechan… - British journal of …, 2001 - Wiley Online Library
Administration of 3,4‐methylenedioxymethamphetamine (MDMA, ‘ecstasy’) to mice produces
acute hyperthermia and long‐term degeneration of striatal dopamine nerve terminals. …
acute hyperthermia and long‐term degeneration of striatal dopamine nerve terminals. …
Amphetamine treatment similar to that used in the treatment of adult attention-deficit/hyperactivity disorder damages dopaminergic nerve endings in the striatum of …
GA Ricaurte, AO Mechan, J Yuan… - … of Pharmacology and …, 2005 - ASPET
Pharmacotherapy with amphetamine is effective in the management of attention-deficit/hyperactivity
disorder (ADHD), now recognized in adults as well as in children and adolescents. …
disorder (ADHD), now recognized in adults as well as in children and adolescents. …
A comparison of learning and memory characteristics of young and middle-aged wild-type mice in the IntelliCage
AO Mechan, A Wyss, H Rieger, MH Mohajeri - Journal of neuroscience …, 2009 - Elsevier
We have tested the cognitive abilities of young (2.5 months) and middle-aged (14 months)
wild-type C57Bl/6J mice in the IntelliCage, which enables automated monitoring of …
wild-type C57Bl/6J mice in the IntelliCage, which enables automated monitoring of …
Monoamine reuptake inhibition and mood-enhancing potential of a specified oregano extract
AO Mechan, A Fowler, N Seifert, H Rieger… - British journal of …, 2011 - cambridge.org
A healthy, balanced diet is essential for both physical and mental well-being. Such a diet
must include an adequate intake of micronutrients, essential fatty acids, amino acids and …
must include an adequate intake of micronutrients, essential fatty acids, amino acids and …
A study of the effect of a single neurotoxic dose of 3, 4-methylenedioxymethamphetamine (MDMA;" ecstasy") on the subsequent long-term behaviour of rats in the plus …
AO Mechan, PM Moran, MJ Elliott, AM Young… - …, 2002 - Springer
Rationale: Decreased 5-HT function has been shown to induce behaviour consistent with an
"anxiolytic" effect. Administration of a single dose of 3,4-methylenedioxymethamphetamine (…
"anxiolytic" effect. Administration of a single dose of 3,4-methylenedioxymethamphetamine (…
A neurotoxic dose of 3, 4-methylenedioxymethamphetamine (MDMA; ecstasy) to rats results in a long term defect in thermoregulation
Rationale: 3,4-Methylenedioxymethamphetamine (MDMA; "ecstasy") administration to rats
produces damage to cerebral 5-HT nerve endings; however, the long-term functional …
produces damage to cerebral 5-HT nerve endings; however, the long-term functional …
Identification and characterization of metallothionein-1 and-2 gene expression in the context of (±) 3, 4-methylenedioxymethamphetamine-induced toxicity to brain …
In mice, the recreational drug (±)3,4-methylenedioxymethamphetamine [MDMA (“ecstasy”)]
produces a selective toxic effect on brain dopamine (DA) neurons. Using cDNA microarray …
produces a selective toxic effect on brain dopamine (DA) neurons. Using cDNA microarray …