The percentage of new chemical entities synthesised with low aqueous solubility and high
therapeutic efficacy is growing, this presents major challenges for the drug delivery scientists. …

The absorption of oral drugs is frequently plagued by significant variability with potentially
serious therapeutic consequences. The source of variability can be traced back to …

The microbiome plays a key role in health and disease, and there has been considerable
interest in therapeutic targeting of the microbiome as well as mining this rich resource in drug …

The drug efflux pump P‐glycoprotein (P‐gp) plays an important role in the function of the
blood–brain barrier by selectively extruding certain endogenous and exogenous molecules, …

This article is aimed to overview the lipid-based nanostructures designed so far for the oral
administration of peptides and proteins, and to analyze the influence of their composition and …

Although oral drug delivery is the preferred administration route and has been used for centuries,
modern drug discovery and development pipelines challenge conventional formulation …

Ghrelin is the only known peripherally-derived orexigenic hormone, increasing appetite and
subsequent food intake. The ghrelinergic system has therefore received considerable …

The significance of the gut microbiota as a determinant of drug pharmacokinetics and accordingly
therapeutic response is of increasing importance with the advent of modern medicines …

The objectives of this study were to characterise three prototype fenofibrate lipid-based
formulations using a range of in vitro tests with differing levels of complexity and to assess the …

The fate and activity of drugs are frequently dictated not only by the host per se but also by
the microorganisms present in the gastrointestinal tract. The gut microbiome is known to, both …