Antioxidant superoxide dismutase-a review: its function, regulation in the testis, and role in male fertility

DD Mruk, B Silvestrini, M Mo, CY Cheng - Contraception, 2002 - Elsevier
… For example, rat SOD EX has a low affinity for heparin (type B SOD EX has weak affinity
for heparin), does not bind to heparan sulfate in vivo, and is a dimeric protein [35], [36], [37], [38], …

Environmental toxicants and male reproductive function

…, J Mannu, PP Mathur, M Bonanomi, B Silvestrini… - …, 2011 - Taylor & Francis
… a, b) and BPA (B:a, b) with a Cx26-based GJ communicating channel. The Panel a in A or B
illustrates the top view of the corresponding docked complex and Panel b in A or B illustrates …

AF-2364 [1-(2, 4-dichlorobenzyl)-1H-indazole-3-carbohydrazide] is a potential male contraceptive: a review of recent data

CY Cheng, D Mruk, B Silvestrini, M Bonanomi… - Contraception, 2005 - Elsevier
… Yan Cheng a , Dolores Mruk a , Bruno Silvestrini b , Michele Bonanomi b , Ching-Hang …
3B and M) were similar to serum (Fig. 3A) and all other organs examined (Fig. 3C–L and N–…

Lonidamine, a selective inhibitor of aerobic glycolysis of murine tumor cells

…, MG Paggi, ML Marcante, B Silvestrini… - Journal of the …, 1981 - academic.oup.com
b For the hepatocytes the values are given for 3XI0· cells. … In: Caputo A, Silvestrini B, eds.
Effects of l-substituted-indazole-3-carboxylic acids on spermatogenesis and cell differentiation …

Effect of lonidamine on the energy metabolism of Ehrlich ascites tumor cells

…, S D'Atri, C De Martino, ML Marcante, B Silvestrini… - Cancer research, 1981 - AACR
… 1, b and c). They are swollen, and a rarefaction and loss of the matrix is observed. The …
Scorza Barcellona, P., and Silvestrini, B. Morphological and biochemical modifica tions of rat …

Morphological, histochemical and biochemical studies on germ cell mitochondria of normal rats

…, PS Barcellona, M Bellocci, B Silvestrini - Cell and tissue …, 1979 - Springer
Morphological changes in rat germ cell mitochondria are described. In diplotene and
secondary spermatocytes and in the spermatids of the Golgi, cap and acrosomal phases, the …

Two new male contraceptives exert their effects by depleting germ cells prematurely from the testis

CY Cheng, B Silvestrini, J Grima, M Mo… - Biology of …, 2001 - academic.oup.com
… During spermatogenesis, pre- and leptotene spermatocytes differentiated from type B
spermatogonia residing near the basal lamina must translocate across the blood-testis barrier, …

Anchoring junctions as drug targets: role in contraceptive development

DD Mruk, B Silvestrini, CY Cheng - Pharmacological reviews, 2008 - ASPET
… in adult mammalian testes, such as the rat, type A spermatogonia in the basal compartment
of the seminiferous epithelium undergo mitotic division to give rise to type B spermatogonia, …

A male contraceptive targeting germ cell adhesion

DD Mruk, CH Wong, B Silvestrini, CY Cheng - Nature Medicine, 2006 - nature.com
… This result was also consistent with in vivo data: the serum inhibin B level remained relatively
unaltered as germ cells were depleted from the seminiferous epithelium in rats treated with …

Environmental toxicants perturb human Sertoli cell adhesive function via changes in F-actin organization mediated by actin regulatory proteins

…, WM Lee, CM John, PJ Turek, B Silvestrini… - Human …, 2014 - academic.oup.com
… 1B suggest that cells exposed to a high dose of either toxicant appeared to be retracting
their cytoplasmic processes, and thus perturbing Sertoli cell barrier function. Also, while …