User profiles for Brian T. Hawkins

Brian T. Hawkins

NC State University
Verified email at ncsu.edu
Cited by 6299

The blood-brain barrier/neurovascular unit in health and disease

BT Hawkins, TP Davis - Pharmacological reviews, 2005 - ASPET
The blood-brain barrier (BBB) is the regulated interface between the peripheral circulation
and the central nervous system (CNS). Although originally observed by Paul Ehrlich in 1885, …

Nicotine increases in vivo blood–brain barrier permeability and alters cerebral microvascular tight junction protein distribution

BT Hawkins, TJ Abbruscato, RD Egleton, RC Brown… - Brain research, 2004 - Elsevier
The blood–brain barrier (BBB) is critical to the health of the central nervous system. The
BBB is formed primarily by the presence of tight junctions (TJ) between cerebral microvessel …

Nicotine and cotinine modulate cerebral microvascular permeability and protein expression of ZO-1 through nicotinic acetylcholine receptors expressed on brain …

TJ Abbruscato, SP Lopez, KS Mark, BT Hawkins… - Journal of …, 2002 - Elsevier
The blood–brain barrier (BBB) adapts to a variety of pathological processes. Little is known
about the effects of nicotine exposure on BBB function and the ability to adapt to stroke …

Chronic inflammatory pain leads to increased blood-brain barrier permeability and tight junction protein alterations

TA Brooks, BT Hawkins, JD Huber… - American Journal …, 2005 - journals.physiology.org
The blood-brain barrier (BBB) maintains brain homeostasis by limiting entry of substances to
the central nervous system through interaction of transmembrane and intracellular proteins …

Fluorescence imaging of blood–brain barrier disruption

BT Hawkins, RD Egleton - Journal of neuroscience methods, 2006 - Elsevier
Pathological alterations of the blood–brain barrier (BBB) can be topographically heterogeneous.
The goal of this study was to develop a method to assess rapidly the magnitude and …

Interendothelial Claudin-5 Expression Depends on Cerebral Endothelial Cell–Matrix Adhesion by β1-Integrins

…, M Kanazawa, Y Tsubota, BT Hawkins… - Journal of Cerebral …, 2011 - journals.sagepub.com
The hypothesis tested by these studies states that in addition to interendothelial cell tight
junction proteins, matrix adhesion by β 1 -integrin receptors expressed by endothelial cells …

Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain

RE Cannon, JC Peart, BT Hawkins… - Proceedings of the …, 2012 - National Acad Sciences
P-glycoprotein, an ATP-driven drug efflux pump, is a major obstacle to the delivery of small-molecule
drugs across the blood-brain barrier and into the CNS. Here we test a unique …

Smoking and ischemic stroke: a role for nicotine?

BT Hawkins, RC Brown, TP Davis - Trends in pharmacological sciences, 2002 - cell.com
Cigarette smoking is a preventable risk factor for ischemic stroke. The mechanisms by which
smoking contributes to stroke are poorly understood and the role of nicotine in this process …

[HTML][HTML] Three-dimensional (3D) tetra-culture brain on chip platform for organophosphate toxicity screening

Y Koo, BT Hawkins, Y Yun - Scientific reports, 2018 - nature.com
Organophosphate-based compounds (OPs) represent a significant threat to warfighters (nerve
agents) and civilian populations (pesticides). There is a pressing need to develop in vitro …

[HTML][HTML] Aryl hydrocarbon receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier

X Wang, BT Hawkins, DS Miller - The FASEB Journal, 2011 - ncbi.nlm.nih.gov
Many widespread and persistent organic pollutants, eg, 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin
(TCDD), activate the aryl hydrocarbon receptor (AhR), causing it to translocate to the cell …