Although drugs are intended to be selective, at least some bind to several physiological
targets, explaining side effects and efficacy. Because many drug–target combinations exist, it …

A newly described coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
which is the causative agent of coronavirus disease 2019 (COVID-19), has …

We evolved muscarinic receptors in yeast to generate a family of G protein-coupled receptors
(GPCRs) that are activated solely by a pharmacologically inert drug-like and bioavailable …

Salvia divinorum, whose main active ingredient is the neoclerodane diterpene Salvinorin A,
is a hallucinogenic plant in the mint family that has been used in traditional spiritual …

Serotonin is perhaps best known as a neurotransmitter that modulates neural activity and a
wide range of neuropsychological processes, and drugs that target serotonin receptors are …

The identification of protein function based on biological information is an area of intense
research. Here we consider a complementary technique that quantitatively groups and relates …

Background: This report provides histopathological evidence to support prior neuroimaging
findings of decreased volume and altered metabolism in the frontal cortex in major …

To understand brain function, it is essential that we discover how cellular signaling specifies
normal and pathological brain function. In this regard, chemogenetic technologies represent …

Atypical antipsychotic drugs have revolutionized the treatment of schizophrenia and related
disorders. The current clinically approved atypical antipsychotic drugs are characterized by …

Several different neuronal populations are involved in regulating energy homeostasis. Among
these, agouti-related protein (AgRP) neurons are thought to promote feeding and weight …