Outcomes for extremely premature infants

HC Glass, AT Costarino, SA Stayer, CM Brett… - Anesthesia & …, 2015 - journals.lww.com
Premature birth is a significant cause of infant and child morbidity and mortality. In the United
States, the premature birth rate, which had steadily increased during the 1990s and early …

The pharmacogenetics research network: from SNP discovery to clinical drug response

KM Giacomini, CM Brett, RB Altman… - Clinical …, 2007 - Wiley Online Library
The NIH Pharmacogenetics Research Network (PGRN) is a collaborative group of investigators
with a wide range of research interests, but all attempting to correlate drug response with …

Role of organic cation transporters in drug absorption and elimination

L Zhang, CM Brett, KM Giacomini - Annual Review of …, 1998 - annualreviews.org
… However, some of the intestinal epithelia are leaky (resistance less than 100 Ω cm 2 )
while other sites are tight (∼500 Ω cm 2 ) (Table 1). Leaky epithelia cannot maintain steep …

[HTML][HTML] Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action

…, L Yue, JC Lo, EG Burchard, CM Brett… - The Journal of …, 2007 - Am Soc Clin Investig
… Hepatocytes on collagen-coated 6-well plates (1.5 × 10 5 cell/cm 2 ) were incubated in
medium containing Matrigel for 16 hours and then were maintained in the regular medium …

Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics

…, L Yue, EG Burchard, CM Brett… - Clinical …, 2008 - Wiley Online Library
The goal of this study was to determine the effects of genetic variation in the organic cation
transporter 1, OCT1, on the pharmacokinetics of the antidiabetic drug, metformin. Twenty …

Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin

…, SW Yee, JH Choi, Y Huang, CM Brett… - Pharmacogenetics …, 2009 - journals.lww.com
Objective The goal of this study was to determine the effect of a genetic variant in the organic
cation transporter 2 (OCT2), OCT2-808G/T, which results in an amino acid change, A270S, …

The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin

…, CA McCarty, RL Davis, CM Brett… - Clinical …, 2013 - Wiley Online Library
Interindividual variation in response to metformin, first‐line therapy for type 2 diabetes, is
substantial. Given that transporters are determinants of metformin pharmacokinetics, we …

Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants

I Badagnani, RA Castro, TR Taylor, CM Brett… - … of Pharmacology and …, 2006 - ASPET
Methotrexate (MTX) is used in patients with malignant and autoimmune diseases. This drug
is primarily excreted unchanged in the urine, and its net excretion occurs via active secretory …

Effects of genetic variation in the novel organic cation transporter, OCTN1, on the renal clearance of gabapentin

…, N Shah, R Mercer, Y Huang, CM Brett… - Clinical …, 2008 - Wiley Online Library
Gabapentin is an anticonvulsant that is widely prescribed for epilepsy and other neuropathic
disorders. The pharmacokinetics, particularly the absorption and renal elimination, of …

CT diagnosis of unsuspected pneumothorax after blunt abdominal trauma

…, MP Federle, RB Jeffrey, CM Brett - American journal of …, 1983 - Am Roentgen Ray Soc
… Our technique for abdominal trauma has been described [ 7 ] and includes contiguous 1
cm sections starting at thetop of the higher hemidiaphragm . Sections throughthe upper …